Alexander the Great changed the face of Judea along with the rest of the then-known world. He reigned as emperor from 356 to 323. BCE In 336 BCE he became king of Macedonia and of the Greek city-states conquered by his father, Philip II. Within a decade he defeated the Persians and fell heir to their empire.
As far as I am aware the following observations were first made by Theodore Weedon (author of 'Mark: traditions in conflict') in informal email discussion.
Jesus in the Gospel of Mark